RT Journal Article
SR Electronic
T1 Genomic Strategies for Diabetic Nephropathy
JF Journal of the American Society of Nephrology
JO J. Am. Soc. Nephrol.
FD American Society of Nephrology
SP S271
OP S278
DO 10.1097/01.ASN.0000078035.81397.8A
VO 14
IS suppl 3
A1 Susztak, Katalin
A1 Sharma, Kumar
A1 Schiffer, Mario
A1 McCue, Peter
A1 Ciccone, Emilio
A1 Böttinger, Erwin P.
YR 2003
UL http://jasn.asnjournals.org/content/14/suppl_3/S271.abstract
AB ABSTRACT. Insight into the molecular mechanisms that underlie the origin and progression of diabetic nephropathy remains limited in part because conventional research tools have restricted investigators to focus on single genes or isolated pathways. Microarray technologies provide opportunities for evaluating genetic factors and environmental effects at a genomic scale during the pathogenesis of diabetic nephropathy. Despite the enormous power of the microarray technology, there are several pitfalls that need to be considered. This article discusses conceptual, practical, statistical, and logistical considerations for the use of microarrays in studies of experimental and human diabetic renal disease. New knowledge in this field will facilitate new approaches for molecular diagnosis and drug discovery. E-mail: ksusztak@aecom.yu.edu