RT Journal Article
SR Electronic
T1 Mechanisms in Hyperkalemic Renal Tubular Acidosis
JF Journal of the American Society of Nephrology
JO J. Am. Soc. Nephrol.
FD American Society of Nephrology
SP 251
OP 254
DO 10.1681/ASN.2008020166
VO 20
IS 2
A1 Karet, Fiona E.
YR 2009
UL http://jasn.asnjournals.org/content/20/2/251.abstract
AB The form of renal tubular acidosis associated with hyperkalemia is usually attributable to real or apparent hypoaldosteronism. It is therefore a common feature in diabetes and a number of other conditions associated with underproduction of renin or aldosterone. In addition, the close relationship between potassium levels and ammonia production dictates that hyperkalemia per se can lead to acidosis. Here I describe the modern relationship between molecular function of the distal portion of the nephron, pathways of ammoniagenesis, and hyperkalemia.