RT Journal Article
SR Electronic
T1 High Altitude Renal Syndrome (HARS)
JF Journal of the American Society of Nephrology
JO J. Am. Soc. Nephrol.
FD American Society of Nephrology
SP 1963
OP 1968
DO 10.1681/ASN.2010121316
VO 22
IS 11
A1 Arestegui, Abdias Hurtado
A1 Fuquay, Richard
A1 Sirota, Jeffrey
A1 Swenson, Erik R.
A1 Schoene, Robert B.
A1 Jefferson, J. Ashley
A1 Chen, Wei
A1 Yu, Xue-qing
A1 Kelly, Jackeline Pando
A1 Johnson, Richard J.
A1 Escudero, Elizabeth
YR 2011
UL http://jasn.asnjournals.org/content/22/11/1963.abstract
AB More than 140 million people live permanently at high altitude (>2400 m) under hypoxic conditions that challenge basic physiology. Here we present a short historical review of the populating of these regions and of evidence for genetic adaptations and environmental factors (such as exposure to cobalt) that may influence the phenotypic responses. We also review some of the common renal physiologic responses focusing on clinical manifestations. The frequent presentation of systemic hypertension and microalbuminuria with relatively preserved GFR coupled with the presence of polycythemia and hyperuricemia suggests a new clinical syndrome we term high altitude renal syndrome (HARS). ACE inhibitors appear effective at reducing proteinuria and lowering hemoglobin levels in these patients.