RT Journal Article
SR Electronic
T1 Global Cardiovascular and Renal Outcomes of Reduced GFR
JF Journal of the American Society of Nephrology
JO J. Am. Soc. Nephrol.
FD American Society of Nephrology
SP 2167
OP 2179
DO 10.1681/ASN.2016050562
VO 28
IS 7
A1 Thomas, Bernadette
A1 Matsushita, Kunihiro
A1 Abate, Kalkidan Hassen
A1 Al-Aly, Ziyad
A1 Ärnlöv, Johan
A1 Asayama, Kei
A1 Atkins, Robert
A1 Badawi, Alaa
A1 Ballew, Shoshana H.
A1 Banerjee, Amitava
A1 Barregård, Lars
A1 Barrett-Connor, Elizabeth
A1 Basu, Sanjay
A1 Bello, Aminu K.
A1 Bensenor, Isabela
A1 Bergstrom, Jaclyn
A1 Bikbov, Boris
A1 Blosser, Christopher
A1 Brenner, Hermann
A1 Carrero, Juan-Jesus
A1 Chadban, Steve
A1 Cirillo, Massimo
A1 Cortinovis, Monica
A1 Courville, Karen
A1 Dandona, Lalit
A1 Dandona, Rakhi
A1 Estep, Kara
A1 Fernandes, João
A1 Fischer, Florian
A1 Fox, Caroline
A1 Gansevoort, Ron T.
A1 Gona, Philimon N.
A1 Gutierrez, Orlando M.
A1 Hamidi, Samer
A1 Hanson, Sarah Wulf
A1 Himmelfarb, Jonathan
A1 Jassal, Simerjot K.
A1 Jee, Sun Ha
A1 Jha, Vivekanand
A1 Jimenez-Corona, Aida
A1 Jonas, Jost B.
A1 Kengne, Andre Pascal
A1 Khader, Yousef
A1 Khang, Young-Ho
A1 Kim, Yun Jin
A1 Klein, Barbara
A1 Klein, Ronald
A1 Kokubo, Yoshihiro
A1 Kolte, Dhaval
A1 Lee, Kristine
A1 Levey, Andrew S.
A1 Li, Yongmei
A1 Lotufo, Paulo
A1 El Razek, Hassan Magdy Abd
A1 Mendoza, Walter
A1 Metoki, Hirohito
A1 Mok, Yejin
A1 Muraki, Isao
A1 Muntner, Paul M.
A1 Noda, Hiroyuki
A1 Ohkubo, Takayoshi
A1 Ortiz, Alberto
A1 Perico, Norberto
A1 Polkinghorne, Kevan
A1 Al-Radaddi, Rajaa
A1 Remuzzi, Giuseppe
A1 Roth, Gregory
A1 Rothenbacher, Dietrich
A1 Satoh, Michihiro
A1 Saum, Kai-Uwe
A1 Sawhney, Monika
A1 Schöttker, Ben
A1 Shankar, Anoop
A1 Shlipak, Michael
A1 Silva, Diego Augusto Santos
A1 Toyoshima, Hideaki
A1 Ukwaja, Kingsley
A1 Umesawa, Mitsumasa
A1 Vollset, Stein Emil
A1 Warnock, David G.
A1 Werdecker, Andrea
A1 Yamagishi, Kazumasa
A1 Yano, Yuichiro
A1 Yonemoto, Naohiro
A1 Zaki, Maysaa El Sayed
A1 Naghavi, Mohsen
A1 Forouzanfar, Mohammad H.
A1 Murray, Christopher J.L.
A1 Coresh, Josef
A1 Vos, Theo
A1 ,
A1 ,
A1 ,
YR 2017
UL http://jasn.asnjournals.org/content/28/7/2167.abstract
AB The burden of premature death and health loss from ESRD is well described. Less is known regarding the burden of cardiovascular disease attributable to reduced GFR. We estimated the prevalence of reduced GFR categories 3, 4, and 5 (not on RRT) for 188 countries at six time points from 1990 to 2013. Relative risks of cardiovascular outcomes by three categories of reduced GFR were calculated by pooled random effects meta-analysis. Results are presented as deaths for outcomes of cardiovascular disease and ESRD and as disability-adjusted life years for outcomes of cardiovascular disease, GFR categories 3, 4, and 5, and ESRD. In 2013, reduced GFR was associated with 4% of deaths worldwide, or 2.2 million deaths (95% uncertainty interval [95% UI], 2.0 to 2.4 million). More than half of these attributable deaths were cardiovascular deaths (1.2 million; 95% UI, 1.1 to 1.4 million), whereas 0.96 million (95% UI, 0.81 to 1.0 million) were ESRD-related deaths. Compared with metabolic risk factors, reduced GFR ranked below high systolic BP, high body mass index, and high fasting plasma glucose, and similarly with high total cholesterol as a risk factor for disability-adjusted life years in both developed and developing world regions. In conclusion, by 2013, cardiovascular deaths attributed to reduced GFR outnumbered ESRD deaths throughout the world. Studies are needed to evaluate the benefit of early detection of CKD and treatment to decrease these deaths.