Table 3.

Effect of phlorizin on fractional and absolute reabsorption (FR, AR) of fluid and electrolyte upstream to the early distal tubule, early distal tubular concentrations of electrolyte ([]ED), early distal tubular delivery of fluid (VED) and electrolyte (D), as well as SNGFR in control and diabetic ratsa

VariableControl (n = 12/4)Diabetes Mellitus (n = 15/4)
Basal/+ PhlorizinΔBasal/+ PhlorizinΔ
aData are mean ± SEM. n = number of nephrons/number of rats. Δ, absolute change.
bP < 0.05 versus control under basal conditions.
cP < 0.05 versus control.
FR-fluid (%)79 ± 2/68 ± 2-11 ± 284 ± 2b/64 ± 4-21 ± 2c
FR-Na+ (%)97 ± 1/95 ± 1-2 ± 199 ± 1b/94 ± 1-5 ± 1c
FR-Cl- (%)96 ± 1/92 ± 1-4 ± 198 ± 1b/92 ± 1-7 ± 1c
FR-K+ (%)95 ± 1/94 ± 1-1 ± 197 ± 1b/91 ± 2-6 ± 1c
AR-fluid (nl/min)33 ± 1/30 ± 2-3 ± 144 ± 2b/26 ± 2-18 ± 3c
AR-Na+ (nmol/min)5.9 ± 0.3/6.1 ± 0.30.1 ± 0.27.1 ± 0.2b/5.3 ± 0.3-1.8 ± 0.4c
AR-Cl- (nmol/min)4.2 ± 0.2/4.3 ± 0.20.1 ± 0.15.3 ± 0.2b/4.0 ± 0.2-1.4 ± 0.3c
AR-K+ (pmol/min)192 ± 11/195 ± 102 ± 6216 ± 7b/155 ± 9-60 ± 12c
VED (nl/min)9 ± 1/14 ± 15 ± 18 ± 1/15 ± 17 ± 1c
[Na+]ED (mM)21 ± 1/23 ± 22 ± 115 ± 2b/25 ± 210 ± 2c
[Cl-]ED (mM)20 ± 1/26 ± 16 ± 116 ± 3b/25 ± 39 ± 2c
[K+]ED (mM)1.2 ± 0.1/1.0 ± 0.1-0.2 ± 0.11.0 ± 0.1b/1.1 ± 0.10.1 ± 0.1c
D-Na+ (pmol/min)193 ± 24/332 ± 40139 ± 26113 ± 21b/361 ± 35247 ± 31c
D-Cl- (pmol/min)184 ± 17/383 ± 37199 ± 19106 ± 13b/353 ± 35246 ± 21c
D-K+ (pmol/min)11 ± 1/14 ± 13 ± 18 ± 1b/17 ± 39 ± 2c
SNGFR (nl/min)43 ± 2/39 ± 2-4 ± 151 ± 2b/35 ± 2-17 ± 3c