Table 1.

Effects of intra-arterial ATP infusion on renal hemodynamics and renal function in NLA-treated dogs (n = 9)a

Parameter Control NLA (50 μg/kg per min) NLA + ATP (1 mg/kg per min)
Systemic arterial pressure (mmHg)143 ± 3.3148 ± 3.4148 ± 3.6
RVR (mmHg/ml per min per g)26.0 ± 1.640.6 ± 2.4b51.5 ± 3.6b,c
RBF (ml/min per g)5.3 ± 0.33.6 ± 0.2b2.8 ± 0.2b,c
GFR (ml/min per g)0.92 ± 0.040.90 ± 0.060.58 ± 0.05b,c
Urine flow (μl/min per g)21.5 ± 4.06.0 ± 0.8b6.1 ± 1.5b
Sodium excretion (μmol/min per g)3.6 ± 0.40.9 ± 0.2b0.6 ± 0.2b
Fractional excretion of sodium (%)2.7 ± 0.40.7 ± 0.2b0.6 ± 0.2b
Potassium excretion (μmol/min per g) 0.7 ± 0.1 0.5 ± 0.06b 0.4 ± 0.04b
  • a ATP, adenosine triphosphate; NLA, nitro-L-arginine; RVR, renal vascular resistance; RBF, renal blood flow.

  • b P < 0.05 versus control period.

  • c P < 0.05 versus NLA period.