Table 2.

Clinical symptoms associated with lithium poisoninga

Organ System Acute Poisoning Chronic Poisoning
EndocrineNoneHypothyroidism
GastrointestinalNausea, vomitingMinimal
HeartProlonged QT interval, ST and T wave changesMyocarditis
HematologicLeukocytosisAplastic anemia
Neurologic
mildFine tremor, lightheadedness, weaknessSame
moderateApathy, drowsiness, hyperreflexia, muscle twitching, slurred speech, tinnitusSame
severeChoreoathetoid movements, clonus, coma, confusion, muscular irritability, seizuresMemory deficits, Parkinson's disease Pseudotumor cerebri, psychosis
NeuromuscularMyopathy, peripheral neuropathySame
RenalUrine concentrating defectChronic interstitial nephritis, nephrogenic diabetes insipidus, renal failure
Skin None Dermatitis, localized edema, ulcers
  • a Data from references 2,3,4.