Table 4.

Drug interactions with lithiuma

Drug Effect on Lithium Concentration
Diuretics
thiazideIncrease
loop diureticsDecrease
osmotic diureticsDecrease
K+ sparingDecrease
methyl xanthineDecrease
acetazolamideDecrease
ACE inhibitorsIncrease
NSAID
indomethacinIncrease
ibuprofenIncrease
mefenamic acidIncrease
naproxenIncrease
sulindacNone
aspirin None
  • a Modified from reference 5. ACE, angiotensin-converting enzyme inhibitors; NSAID, nonsteroidal anti-inflammatory drugs.