Table 5.

Systolic (SBP) and diastolic blood pressure (DBP) in five chronic hemodialysis patients receiving an infusion of big ET-1 in increasing doses, each dose for 20 min

DoseSBP (mmHg)DBP (mmHg)
aP < 0.05 versus basal.
bP < 0.001 versus basal.
cP < 0.01 versus basal.
Basal125 ± 4.876 ± 3.9
0.2 pmol/kg per min131 ± 5.478 ± 4.5
1 pmol/kg per min132 ± 5.8a80 ± 4.0a
4 pmol/kg per min142 ± 4.8b88 ± 3.5b
15 min postinfusion149 ± 6.3b92 ± 4.5b
60 min postinfusion138 ± 4.3b88 ± 4.0b
120 min postinfusion133 ± 5.6c82 ± 4.9c