Table 1.

Acute hemodynamic effects of intravenous TGF-β2 (1.2 μg/kg per min) in volume-replete ratsa

VariableVehicle (n = 16)TGF-β2 (n = 8)
BeforeAfterBeforeAfter
aValues are means ± SEM. BW, body weight; LKW, left kidney weight; MAP, mean arterial pressure; ERPF, effective renal plasma flow; FF, filtration fraction; UV, urine volume; PRC, plasma renin concentration; AngII, angiotensin II; ND, not detectable. There were no differences between groups at baseline.
bP < 0.05 versus baseline.
BW (g)336 ± 7352 ± 8
LKW (g)1.34 ± 0.031.29 ± 0.06
MAP (mmHg)133 ± 3130 ± 4129 ± 4124 ± 4b
GFR (ml/min)1.71 ± 0.081.80 ± 0.071.71 ± 0.081.82 ± 0.20
ERPF (ml/min)5.20 ± 0.205.32 ± 0.165.21 ± 0.345.34 ± 0.59
FF0.33 ± 0.010.34 ± 0.010.34 ± 0.020.33 ± 0.01
UV (ml/min)3.8 ± 0.24.1 ± 0.14.6 ± 1.04.5 ± 0.5
Serum TGF-β2 (pg/ml)ND116 ± 48