Table 2.

Allele frequency and genotype distribution of the C708/T and ScaI polymorphisms of the PND gene in 454 type 1 diabetic patients with or without nephropathy and 58 healthy control subjectsa

Type 1 Diabetic Patients
CategoryNormoalbuminuria ≤20AER (μg/min) Microalbuminuria 20 to 200Macroalbuminuria ≥200Healthy Control SubjectsP Valueb
aPND, pronatriodilatin. Other abbreviations as in Table 1.
bFisher exact test.
Patientsn = 323n = 79n = 52n = 58
genotypes
C708C292 (0.91)61 (0.77)48 (0.92)54 (0.93)0.012
C708T31 (0.09)17 (0.22)4 (0.08)4 (0.07)
T708T01 (0.01)0
Chromosomen = 646n = 158n = 104n = 116
alleles
C708614 (0.95)139 (0.88)100 (0.96)112 (0.96)0.011
T70832 (0.05)19 (0.12)4 (0.04)4 (0.04)
Patientsn = 323n = 79n = 52n = 58
genotypes
A2A2193 (0.60)61 (0.77)46 (0.88)36 (0.62)<0.0001
A2A1124 (0.38)16 (0.21)6 (0.12)21 (0.36)
A1A16 (0.02)2 (0.02)01 (0.02)
Chromosomen = 646n = 158n = 104n = 116
alleles
A2510 (0.79)138 (0.87)98 (0.94)93 (0.80)<0.0001
A1136 (0.21)20 (0.13)6 (0.06)23 (0.20)