Table 3.

Allele frequency and genotype distribution of C708/T and ScaI polymorphisms of the PND gene in type 1 diabetic patients with or without nephropathya

CategoryType 1 Diabetic PatientsP Valueb
Normoalbuminuria ≤20AER (μg/min) Microalbuminuria 20 to 200Macroalbuminuria ≥200
aOnly patients with diabetes duration ≥15 yr are included. Abbreviations as in Tables 1 and 2.
bFisher exact test.
Patients genotypesn = 164n = 60n = 48
C708C148 (0.90)43 (0.72)44 (0.92)0.003
C708T16 (0.10)16 (0.27)4 (0.08)
T708T01 (0.001)0
Chromosome allelesn = 328n = 118n = 96
C708312 (0.95)102 (0.86)92 (0.96)0.003
T70816 (0.05)18 (0.14)4 (0.04)
Patients genotypesn = 164n = 60n = 48
A2A2102 (0.62)47 (0.78)42 (0.88)0.002
A2A159 (0.36)11 (0.19)6 (0.12)
A1A13 (0.02)2 (0.03)0
Chromosome allelesn = 328n = 118n = 96
A2253 (0.80)103 (0.87)90 (0.94)0.001
A165 (0.20)15 (0.13)6 (0.06)