Table 1.

Clinical features, course, and outcome of HCV-associated glomerular diseases in HIV patientsa

CharacteristicPatient
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aM, male; F, female; B, black; H, Hispanic; HBV, hepatitis B virus; sAg, surface antigen; sAb, surface antibody; cAb core antibody; NS, nephrotic syndrome; RI, renal insufficiency; ARF, acute renal failure; C, red cell casts; Cr, serum creatinine; AST, serum aspartate aminotransferase; ALT, serum alanine aminotransferase; Bx, biopsy; CCr, creatinine clearance; S, serum; ND, not done; MPGN-1, type 1 membranoproliferative glomerulonephritis; MPGN-3, type 3 membranoproliferative glomerulonephritis; MGN, membranous glomerulopathy; FSGS, focal segmental glomerulosclerosis; Mes. Prolif., mesangial proliferative; Seg., segmental; TMA, thrombotic microangiopathy; IT, immunotactoid glomerulopathy; NA, not applicable; t (months), time interval in months; PD, peritoneal dialysis; HD, hemodialysis.
Age/gender/race51/M/B44/M/B55/F/B42/F/B40/M/B58/M/B48/F/B37/M/H44/F/B37/M/B44/F/B52/M/B43/F/B38/M/B
HBV sAg/sAb/cAb-/-/+-/-/+-/-/+-/+/-/-/+-/-/+-/+/+-/+/+-/-/+-/-/+-/-/+-/+/+-/-/+-/+/
CD4+ T cells/μl50357536384109832423816074270146250213
PresentationNSNSRINSARFRINSRIRIRINSRINSUremia
BP (mmHg)150/110160/100140/100110/70105/55142/89165/9094/52110/80100/74190/110110/88150/90163/114
Edema3+3+No3+NoNo3+1+NoNo3+1+3+No
Proteinuria (g/24 h)12.817.45.63.33.43.813.70.33.24.7240.04232.7
Microhematuria3+3+/C2+3+/C3+/C2+3+2+1+01+1+3+2+
Cr (mg/dl) at Bx2.53.04.21.82.02.42.61.62.13.02.41.82.216.7
CCr (ml/min)30.357.019.337.040.019.921.251.821.028.647.068.137.25.9
S. albumin (g/dl)1.22.23.62.02.33.01.23.22.12.21.03.13.02.6
S. cholesterol (mg/dl)1742481491965214114190110125267135116
AST/ALT (U/L)73/3552/1850/13108/36127/6289/5746/1734/16120/26103/4423/674/45101/6029/14
HypocomplementemiaNoNoNoYesYesNoYesYesNoNoYesYesNDNo
CryoglobulinemiaNoNoNoYesYesNoNoNoNoYesYesNoNDND
Renal pathologyMPGN-1MPGN-3MGN & FSGSExudative & MGNMPGN-3MPGN-3MPGN-1Mes. Prolif. & Seg. MGNMPGN-1 (?TMA)MPGN-1MPGN-3 (IT)MPGN-1MPGN-1MPGN-3
Peak Cr (mg/dl)16.510.49.22.37.011.64.72.34.16.86.31.94.616.2
t (months) to peak2.22.15.80.3-0.45.30.26.71.10.41.7NA10.20.0
Cr
DialysisPDHDHDNoNoHDNoNoNo?HDNoNoHD
t (months) to dialysis2.42.15.8NANA22.4NANANANA1.8NANA0.0
OutcomesDeathDeathDeathDeathAliveDeathDeathAliveDeathLostAliveDeathAliveAlive
t (months) of follow-up9.345.96.10.628.525.40.228.66.00.420.56.410.45.9