Table 2.

Renal biopsy findingsa

AnalysisPatient
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aImmunofluorescence and electron microscopy are graded on a scale of 0 to 3+. cell, cellular crescent; fibr, fibrous crescent; Mod, moderate; Mes, mesangial; CW, glomerular capillary wall; Neg, negative; NA, not available; TRI, tubuloreticular inclusions; MPGN, membranoproliferative glomerulonephritis; MGN, membranous glomerulopathy; FSGS, focal segmental glomerulosclerosis; MesP & sMGN, mesangial proliferative with segmental membranous features; TMA, thrombotic microangiopathy; IT, immunotactoid.
Light microscopy
no. of glomeruli36211231181872318125421717
no. of sclerotic glomeruli398115062502414
no. of crescents2 (1 cell; 1 fibr)4 (1 cell; 3 fibr)NoneNoneNoneNoneNoneNoneNoneNoneNoneNone3 (2 cell; 1 fibr)7 (3 cell; 4 fibr)
Tubular atrophy/interstitial fibrosisModSevereSevereNoneNoneModModSevereMildModMild-modMildMildSevere
Immunofluorescence
IgG3+Mes/CW3+CW1+Mes/CW2+CWNeg1+Mes/CW2+Mes/CWNegNeg1+Mes3+Mes/CW2+Mes/CW1+Mes/CW1+CW
IgM1+Mes/CW1+Mes/CWNeg2+Mes/CW1+Mes/CW1+CW2+Mes/CWNeg2+Mes3+Mes/CW2+CW2+Mes/CW2+Mes/CW2+CW
IgA+/-Mes/CWNegNeg+/-CWNegNegNegNegNeg1+Mes1+CWNeg1+CWNeg
C33+Mes/CW2+CWNeg1+Mes/CW3+Mes/CW1+CW3+Mes/CW1+Mes/CW2+Mes/CW3+Mes/CW+/-CW3+Mes/CW3+Mes/CW2+CW
C11+CW1+CWNeg3+Mes/CWNegNeg1+CWNeg2+Mes/CWNegNegNeg+/-CW1+CW
Electron microscopy
location of deposits
mesangial2+2+1+2+1+3+NA2+Neg2+3+(fibrils)2+2+1+
subendothelial2++/-NegNeg1+1+1+Neg2+3+(fibrils)1+2+2+
subepithelial+/-3+2+3+1+3+1+NegNeg3+(fibrils)1+1+2+
TRI2+None1+NoneNone3+None3+None1+1+3+2+
Final diagnosisMPGN type 1MPGN type 3MGN & FSGSExudative & MGNMPGN type 3MPGN type 3MPGN type 1MesP & sMGNMPGN type 1 (? TMA)MPGN type 1MPGN type 3 (IT)MPGN type 1MPGN type 1MPGN type 3