Table 4.

Morphologic findings on renal biopsya

CharacteristicAnti-PR3 (n = 17)Anti-MPO (n = 14)Statistical Significance
aResults are given as mean ± SD.
bPercentage of total number of glomeruli.
cPercentage of nonsclerosed glomeruli.
dSemiquantitatively graded on a scale from 0 to 3.
Normal glomeruli (%)b23.4 ± 28.237.5 ± 20.4NS
Glomerular lesions
global sclerosis (%)b21.9 ± 29.118.3 ± 26.9NS
necrosis (%)c28.8 ± 29.110.4 ± 12.8NS (P = 0.07)
cellular crescents (%)c47.6 ± 39.628.0 ± 18.0NS
fibrous crescents (%)c20.1 ± 36.822.1 ± 25.2NS
leukocyte influxd1.3 ± 0.80.7 ± 0.6NS (P = 0.07)
Tubulointerstitial lesionsd
interstitial inflammation1.4 ± 0.71.0 ± 0.7NS
interstitial fibrosis0.7 ± 0.80.9 ± 1.0NS
tubular atrophy0.9 ± 0.90.9 ± 0.8NS
Activity index9.5 ± 5.46.2 ± 3.2P = 0.04
Chronicity index4.3 ± 4.25.0 ± 3.2NS