Table 5.

Degranulation assays using primed healthy donor neutrophilsa

CategoryHealthy Control Subjects (n = 16)Anti-MPO (n = 14)Anti-PR3 (n = 17)fMLP
aResults are expressed as median (interquartile range). fMLP, N-formylmethionylleucylphenylalanine.
bP < 0.01 compared with IgG fractions from healthy control subjects.
cP < 0.01 compared with IgG from anti-MPO-positive patients.
First neutrophil donor
β-glucuronidase (%)8.5 (7.8 to 9.9)8.0 (6.6 to 8.5)10.4 (9.3 to 11.2)b,c30.5
lactoferrin (ng/ml)13 (4 to 28)34 (17 to 41)38 (25 to 60)b95
Second neutrophil donor
β-glucuronidase (%)8.4 (6.5 to 11.0)5.7 (4.9 to 6.3)11.0 (6.8 to 14.6)b,c41.5
lactoferrin (ng/ml)14 (25 to 19)4 (0.5 to 18)55 (23 to 76)b,c87