Table 6.

Correlations between the capacity of the IgG fractions to induce superoxide release and clinical, laboratory, and histopathologic characteristicsa

CharacteristicAnti-PR3 and Anti-MPO (n = 31)Anti-PR3 (n = 17)Anti-MPO (n = 14)
aExpressed as ΔOD 550 nm at 120 min in the ferricytochrome c reduction test with neutrophils from the first neutrophil donor. Abbreviations as in Table 1.
bPercentage of nonsclerosed glomeruli.
cSemiquantitatively graded on a scale from 0 to 3.
No. of affected extrarenal organsr = 0.22; NSr = 0.11; NSr = -0.19; NS
BVASr = 0.08; NSr = 0.07; NSr = -0.31; NS
Serum creatinine (μmol/L)r = 0.05; NSr = -0.03; NSr = -0.04; NS
C-reactive protein level (mg/L)r = -0.08; NSr = -0.37; NSr = -0.007; NS
ANCA titer of the IgG fractionsr = 0.37; P = 0.047r = 0.39; NSr = 0.72; P = 0.004
Glomerular lesions
cellular crescents (%)br = 0.42; P = 0.03r = 0.37; NSr = 0.37; NS
necrosis (%)br = 0.53; P = 0.005r = 0.09; NSr = 0.75; P = 0.003
fibrous crescents (%)br = -0.61; P = 0.0009r = -0.43; NSr = -0.72; P = 0.006
leukocyte influxcr = 0.36; NSr = -0.07; NSr = 0.35; NS
Interstitial lesions
interstitial inflammationcr = 0.12; NSr = -0.15; NSr = 0.09; NS
interstitial fibrosiscr = -0.57; P = 0.002r = -0.30; NSr = -0.79; P = 0.002
tubular atrophycr = -0.46; P = 0.02r = -0.38; NSr = -0.61; P = 0.03
Activity indexr = 0.47; P = 0.02r = 0.17; NSr = 0.56; P = 0.049
Chronicity indexr = -0.59; P = 0.002r = -0.37; NSr = -0.87; P = 0.0001