Table 1.

Comparison of pretransplant and posttransplant characteristicsa

CharacteristicSandimmune + AZA (n = 72)Neoral + MMF (n = 29)P Value
aAZA, azathioprine; MMF, mycophenolate mofetil; PRA, panel reactive antibody; CsA, cyclosporin A.
bValues represent median (minimum, maximum).
cValues are expressed as percentage of individuals experiencing 0, 1, or ≥2 rejection episodes.
dValues are expressed as percentage of individuals experiencing 0 or ≥1 rejection episode.
HLA matchingb2 (0,5)2 (1,4)NS
PRA (%)0.8 ± 0.57.2 ± 3.10.004
Donor age (yr)33 ± 241 ± 20.03
Cold ischemia (min)989 ± 54914 ± 81NS
Delayed graft function22% (16 of 72)27% (8 of 29)NS
CsA level (μg/L)
mean 1 to 2 mo313 ± 7374 ± 9<0.0001
mean 1 to 3 mo307 ± 5359 ± 7<0.0001
Corticosteroid dose (g)
1 to 3 mo6.0 ± 0.34.7 ± 0.40.02
4 to 6 mo2.3 ± 0.22.6 ± 0.3NS
Clinical rejectionc(0, 1, ≥2)c(0, 1, ≥2)
0 to 2 mo16, 42, 4224, 62, 140.03
0 to 3 mo14, 35, 51 (0, ≥1)d24, 48, 28 (0, ≥1)0.03
4 to 6 mo67, 3364, 36NS
7 to 12 mo77, 2390, 100.26
Creatinine (μmol/L)
6 mo136 ± 6143 ± 9NS
12 mo143 ± 9136 ± 7NS