Table 3.

Monocyte-macrophage infiltrationa

ANCA + RVP Values
AntibodiesNKGlomeruliPeriglomerular GranulomasCryoGNANCA + RV vs NKANCA + RV (glomeruli) vs CryoGNCryoGN vs NK
aThe number of positive cells/glomerulus is expressed as mean ± SD of the mean. Minimum and maximum values are in parentheses. NK, normal kidney; ANCA + RV, antineutrophil cytoplasmic antibody-positive renal vasculitis; CryoGN, cryoglobulinemic glomerulonephritis.
Immunohistochemistry
CD680.9 ± 0.4 (0-2)44.8 ± 28.2 (10.2-83.4)163 ± 82.4 (72.7-256.4)64.8 ± 12.3 (48.2-86.4)0.001ns0.001
VCAM-1066.4 ± 15.2 (32.8-89.6)126.4 ± 58 (62.2-196.5)0.03 ± 0.004 (0-2.1)<0.001<0.001ns
HLA class II059.6 ± 10.8 (38.9-86.2)158.1 ± 60 (87.7-220.3)10 ± 2.1 (4.3-15.6)<0.0010.02<0.001
27E10062.8 ± 12.2 (34.3-98.4)198.2 ± 20.8 (150-260.8)19.8 ± 2.4 (10.5-24.2)<0.0010.03<0.001
TNF-α046.7 ± 10.8 (27.3-68.9)142.6 ± 68.9 (45.4-200.2)8.2 ± 1.3 (3.1-12.7)<0.0010.01<0.001
IL-1α039.5 ± 6.2 (20.7-54.2)138.1 ± 62.8 (42.3-198.6)7.4 ± 0.9 (3.9-10.6)<0.0010.01<0.001
PCNA/CD6805 ± 0.4 (0.6-8)13.2 ± 0.6 (10.5-16.2)00.010.01ns
Mib-1/CD6802.04 ± 0.3 (0.4-4.6)4.7 ± 2.1 (1.2-8.8)00.020.02ns
In situ hybridization
TUNEL/CD6801.6 ± 0.7 (0.6-2.3)3.2 ± 0.4 (1.8-4.7)00.010.01ns
mRNA VCAM-1054.9 ± 10.1 (38.6-71.3)106.2 ± 58.6 (49.6-176.2)0<0.001<0.001ns
TNF-α040.6 ± 9.4 (22.2-60.6)110.3 ± 54.2 (19.4-186.2)7.8 ± 2.3 (2.9-14.6)<0.0010.01<0.001
IL-1α031.2 ± 19.8 (4.9-64.2)122.2 ± 63.7 (20.1-196.4)6.4 ± 1.9 (1.8-10.9)<0.0010.01<0.001