Table 2.

Relative risk estimates for CVD (n = 30 events) during follow-up (median, 21.2 mo) derived from proportional hazards modeling with tHcy as a continuous variable, unadjusted, individually adjusted, and with multivariate-adjustment for potential confounding variablesa

CategoryRelative Risk Estimate (95% confidence interval)P Value
aAbbreviations as in Table 1.
tHcy (per μmol/L increase), unadjusted
tHcy (per μmol/L increase), adjusted for
previous CVD1.07 (1.04 to 1.09)<0.001
time on dialysis1.08 (1.06 to 1.10)<0.001
use of cyclosporin A1.08 (1.05 to 1.10)<0.001
diabetes mellitus1.08 (1.06 to 1.10)<0.001
gender1.07 (1.05 to 1.09)<0.001
age1.08 (1.06 to 1.10)<0.001
smoking1.08 (1.04 to 1.09)<0.001
hypertension1.07 (1.05 to 1.10)<0.001
total cholesterol1.08 (1.06 to 1.11)<0.001
triglycerides1.08 (1.05 to 1.10)<0.001
creatinine1.07 (1.05 to 1.09)<0.001
Final multivariate-adjusted model
total homocysteine (per mmol/L increase)1.06 (1.04 to 1.09)<0.001
creatinine (per 50 mmol/L increase)1.34 (1.08 to 1.66)<0.01
age (per 10-yr increase)1.55 (1.09 to 2.19)=0.01
gender (male versus female)3.03 (0.88 to 11.11)=0.07
baseline CVD1.28 (0.54 to 3.02)=0.58
transplant duration1.00 (0.99 to 1.01)=0.71