Table 1.

Measurement of changes in db/db mice at 5 moa

CharacteristicControl db/mDiabetic db/dbP Value
aProtein excretion was determined in two consecutive 24-h urine collections. The mean value of these two collections was taken as the degree of proteinuria. A total of 100 to 150 glomeruli per kidney were scored on a scale of 0 to 4 as described in Materials and Methods. All values are means ± SEM.
Blood glucose142 ± 19.0 mg/dl (n = 8)485 ± 58.0 (n = 6)<0.001
Weight29.2 ± 1.00 g (n = 8)43.1 ± 7.30 (n = 6)<0.001
Proteinuria2.32 ± 1.07 mg/24 h (n = 10)2.78 ± 0.93 (n = 9)0.330
Glomerular sclerosis0.101 ± 0.048 (n = 17)0.649 ± 0.369 (n = 6)0.003