Table 1.

Blood glucose and serum cholesterol levels in normal control and diabetic ratsa

GroupBlood Glucose Level (mg/dl)
7 Days14 Days1 Month3 Months6 Months12 Months
aTail venous blood glucose level was measured using a reflectance meter (Reflolux S, Boehringer Mannheim, Mannheim, Germany). Serum cholesterol was measured by an enzyme-linked (cholesterol hydrolase/cholesterol oxidase/peroxidase) colorimetric method using Cholesterol-E kit (Yeong Dong Pharmaceutical Co., Kyunggi, Korea). Values are given as mean ± SEM, and the numbers in parentheses represent the number of animals examined. NC, age-matched normal control rats; DD, untreated diabetic rats; DL, diabetic rats treated with lovastatin.
bP < 0.05 DD versus NC.
cP < 0.05 DL versus NC.
dP < 0.05 DL versus DD.
NC168 ± 5 (12)167 ± 13 (12)189 ± 13 (12)192 ± 22 (11)201 ± 36 (11)210 ± 57 (10)
DD460 ± 15 (12)b470 ± 10 (12)b490 ± 15 (11)b510 ± 21 (11)b528 ± 29 (9)b555 ± 41 (7)b
DL472 ± 18 (12)c477 ± 13 (12)c502 ± 16 (10)c505 ± 37 (10)c532 ± 59 (9)c540 ± 38 (7)c
Serum Cholesterol (mg/dl)
NC62 ± 16 (12)58 ± 1 (12)62 ± 13 (12)79 ± 6 (11)58 ± 5 (11)57 ± 3 (10)
DD67 ± 5 (12)58 ± 7 (12)71 ± 2 (11)67 ± 5 (11)87 ± 16 (9)b69 ± 5 (7)
DL60 ± 4 (12)55 ± 4 (12)73 ± 4 (10)57 ± 4 (10)62 ± 10 (7)d51 ± 5 (6)d