Table 3.

Factor affecting graft survival function: Cox regression univariate analysisa

Graft Survival Time
VariableInterval 1 ≤6 moInterval 2 6 mo to 5 yrInterval 3 >5 yrAll Intervals
HR (95% CI)P ValueHR (95% CI)P ValueHR (95% CI)P ValueHR (95% CI)P Value
aHR, hazard ratio; CI, confidence interval. Other abbreviations as in Table 2.
bIn interval 1, we included only the rejections occurring before 6 mo. Otherwise, we included all rejections requiring antibody therapy.
Donor age ≥55 yr1.88 (0.88 to 4.00)0.1041.20 (0.48 to 3.00)0.705.87 (1.92 to 17.94)0.0021.88 (1.13 to 3.14)0.016
Donor female1.06 (0.60 to 1.89)0.831.43 (0.86 to 2.39)0.172.31 (0.98 to 5.45)0.0571.39 (0.98 to 1.96)0.07
Recipient age ≥55 yr0.74 (0.36 to 1.51)0.410.40 (0.17 to 0.93)0.031.13 (0.37 to 3.37)0.830.62 (0.38 to 1.01)0.055
Recipient female1.25 (0.72 to 2.16)0.421.01 (0.60 to 1.70)0.970.75 (0.30 to 1.87)0.541.05 (0.74 to 1.49)0.78
HLA-A,B mismatch >21.53 (0.84 to 2.78)0.161.14 (0.67 to 1.93)0.630.89 (0.37 to 2.13)0.801.22 (0.86 to 1.75)0.27
HLA-DR mismatch > 11.91 (1.11 to 3.29)0.0191.24 (0.72 to 2.12)0.430.44 (0.15 to 1.30)0.171.29 (0.90 to 1.83)0.16
PRA high ≥50%2.64 (1.44 to 4.84)0.0020.99 (0.47 to 2.08)0.970.99 (0.29 to 3.35)0.981.54 (1.00 to 2.37)0.048
PRA recent ≥50%1.30 (0.46 to 3.61)0.621.67 (0.72 to 3.88)0.240.72 (0.10 to 5.37)0.751.36 (0.73 to 2.53)0.33
SCr at 6 mo ≥ 150NA4.58 (2.64 to 7.95)<0.0012.01 (0.85 to 4.75)0.113.64 (2.31 to 5.73)<0.001
DGF2.30 (1.34 to 3.94)0.0021.93 (1.16 to 3.19)0.0111.22 (0.50 to 2.94)0.671.93 (1.37 to 2.70)<0.001
Rejection ABb4.75 (2.77 to 8.14)<0.0013.81 (2.31 to 6.29)<0.0011.11 (0.40 to 3.03)0.843.17 (2.26 to 4.45)<0.001