Table 1.

NF-κB decoy ODN treatment inhibits histologic damage in rat anti-GBM disease a

LesionNormal KidneyScrambled ODN-Treated Anti-GBM DiseaseNF-κB Decoy ODN-Treated Anti-GBM Disease
aNF-κB, nuclear factor-κB ; ODN, oligodeoxynucleotide ; GBM, glomerular basement membrane ; gcs, glomerular cross section.
bP < 0.001 versus normal by ANOVA.
cP < 0.01 versus scrambled by ANOVA.
dP < 0.05 versus scrambled by t test.
Glomerular cellularity (cells/gcs)56.3 ± 8.6100.3 ± 12.9 b78 ± 6 c
Focal glomerular sclerosis (%)028.5 ± 9.09.6 ± 5.9 d
Glomerular crescents (%)020.5 ± 9.94.4 ± 2.0 d
Interstitial lesions (%)032.9 ± 21.78.4 ± 2.7 d