Table 1.

Murine PKD models a

MutationInheritanceRenal Pathology bChromosome cQTL Intervals d
aPKD, polycystic kidney disease ; QTL, quantitative trait loci ; AR, autosomal recessive ; AD, autosomal dominant ; PT, proximal tubule.
bThe nephron segments in which the predominant cystic lesion is expressed.
cChromosome to which the locus has been mapped.
dQTL interval is identified by the closest microsatellite marker ; + indicates evidence for genetic background effect, but no QTL mapping data are available.
eThe model arose as a spontaneous mutation.
fThe model was experimentally induced.
gThese mutations are allelic.
Mouse models
cpk eARCollecting duct12 D4Mit111
bpk eARCollecting duct10 gThis study
orpk fARCollecting duct14+
jck eAREntire nephron11 D1Mit42 ; D1Mit150 ; D10Mit10
pcy eAREntire nephron9 D4Mit111 ; D16Mit74
jcpk fAD/ARGlomerulus10 g
kat eARGlomerulus ; PT8 D1Mit8 ; D19Mit11
kd eARNot well defined10
bcl-2 fARNot well defined1
Krd fADNot well defined19
Rat models
Cy eAD/AREntire nephron5
wpk eARCollecting duct5