Table 2.

Mean cefazolin and tobramycin pharmacokinetic parameters on and off cycler a

Drugkel (h-1) Dwell 1 to 3t1/2 (h) Dwell 1 to 3kel (h-1) Dwell 4 to 5t1/2 (h) Dwell 4 to 5ksd (h-1) Dwell 1 to 3t1/2 ksd (h) Dwell 1 to 3Vd (L/kg)
akel, serum elimination rate ; t1/2, half-life ; ksd, serum to dialysate transfer rate ; Vd, volume of distribution.
Cefazolin
mean0.0810.670.0323.090.561.250.14
SD0.034.660.015.600.030.070.03
Tobramycin
mean0.0514.270.0168.500.491.470.21
SD0.014.530.0026.470.100.280.06