Table 2.

Clinical, histologic, and immunologic characteristics of published cases of renal diseases associated with hepatitis C infection after renal transplantation a

Liver DiseaseRenal DiseaseImmunologic Data
StudyNo. of Patients/ % HCV SeriesHCV Viremia/HCV GenotypeElevated ALTACH/CirrhosisTime of Presentation (mo)Nephrotic Proteinuria at BxLesionType of LesionRF+CryoglobulinsC3 ↓C4 ↓Serum ICACA+
aModified from Curr Opin Nephrol Hypertens 6 : 511-515, 1997. ACH, active chronic hepatitis ; ALT, alanine aminotransferase ; Bx, biopsy ; ↓, decreased ; HCV, hepatitis C virus ; IC, immunocomplex ; MGN, membranous glomerulonephritis ; MPGN, membranoproliferative glomerulonephritis ; NA, not available ; ND, not done ; RF, rheumatoid factor ; Tx, transplant ; ACA, anticardiolipin antibody ; RTMA, renal thrombotic microangiopathy.
Roth et al. (61)5 of 98 (5)All/ND3 (60%)1/none51 (2 to 120)5 (100%)MPGN De novo 1 (20%)Negative1 (20%)2 (40%)1 (20%)ND
Cruzado et al. (60)6 of 94 (6.3)All/5 : 1b3 (50%)None/none52 to 55 (20 to 118)3 (50%)MPGN De novo 1 (16%)6 (100%)6 (100%)6 (100%)6 (100%)ND
1 : 2a
Brunkhorst et al. (63)1/NA+/NDNoNo24YesMPGNRecurrentNDNegativeYesYesNDND
Hammoud et al. (62)7 of 117 (5.9)NANANANANAMPGN1 recurrent1 (14%)2 (28%)3 (43%)NANDND
6 de novo
5 of 117 (4.5)NANANANA3 (60%)MGN1 recurrentNANANANANDND
4 de novo
Morales et al. (64)15 of 40914/147 (46.6%)None/none18.2 (4 to 56)10 (66.6%)MGN2 recurrentNoneNegativeNoneNoneNDND
(3.6%)(100%)/9 : 1b13 de novo
2:3a
2:2
1:4
Gallay et al. (58)2/NA+/NA1 (50%)No/No54 (36 to 72)2 (100%)TxGN1 (50%)1 (50%)1 (50%)1 (50%)NDND
Cosío et al. (58)9 of 27 (33%)NA/NANANANANATxGNNoNoneNANANAND
12 of 41 (29%)NA/NANANANANAAcute TxGNNoNegativeNANANAND
Baid et al. (65)5 of 18 (28%)NANANA14 days (5 to 120)NARTMA De novo NoNegativeNoNoNAYes