Table 3.

Risk factors for IHD events occurring >1 yr after renal transplantationa

VariableFull ModelStratified Model
Relative Risk95% CIP ValueRelative Risk95% CIP Value
aCox proportional-hazards models (n = 1124 transplants and 123 IHD events), with and without stratification for renal disease from type I diabetes mellitus, which violates the proportional-hazards assumption, were used. Shown are relative risks, 95% confidence intervals, P values, and (in parentheses) the proportion of patients having the characteristic indicated by that variable. A relative risk greater or less than 1.00 indicates a higher or lower risk for IHD, respectively. Included in the models, but not in the table, were variables testing the effects of missing values (each with P > 0.5). ESRD, end-stage renal disease; PKD, polycystic kidney disease.
ESRD, type I diabetes mellitus (0.18)3.031.75 to 5.240.000
ESRD, type I diabetes mellitus in women (0.07)2.311.09 to 4.860.0282.301.09 to 4.850.029
ESRD, type II diabetes mellitus (0.07)2.791.26 to 6.170.0122.761.24 to 6.140.013
ESRD, type II diabetes mellitus in women (0.03)3.350.99 to 11.30.0523.230.96 to 10.90.033
Nonrenal disease diabetes (0.04)2.541.15 to 5.600.0212.591.17 to 5.710.051
Age (1.00, mean = 41.8 yr)1.061.04 to 1.080.0001.061.04 to 1.080.000
Age in women (0.44, mean = 41.5 yr)0.990.97 to 0.990.0000.980.97 to 0.990.000
Smoking at transplant (0.25)1.851.23 to 2.760.0031.871.25 to 2.800.002
Transplant in 1986 to 1992 (0.35)0.600.39 to 0.920.0190.590.38 to 0.910.018
Transplant after 1992 (0.26)0.270.11 to 0.630.0020.260.11 to 0.610.002
Two or more 1st year rejections (0.16)1.621.04 to 2.530.0341.621.04 to 2.530.034
Bilateral nephrectomy (0.29)0.450.26 to 0.770.0040.450.26 to 0.780.004
Bilateral nephrectomy for PKD (0.04)3.451.50 to 7.950.0043.501.52 to 8.060.003
Serum albumin levels of <4.0 mg/dl (0.54)1.711.10 to 2.650.0171.711.10 to 2.660.017
Proteinuria (0.17)1.691.08 to 2.640.0221.651.06 to 2.580.028
Cholesterol levels of >200 mg/dl (0.77)2.181.01 to 4.720.0482.181.01 to 4.730.048
Triglyceride levels of >350 mg/dl (0.07)1.901.04 to 3.470.0381.881.03 to 3.440.040