Table 1.

Animal dataa

Groups No. of Animals Body Weight (g) Plasma Urea Concentration (mg/dl) Plasma Creatinine Concentration (mg/dl) Hemoglobin Level (g/dl) Systolic BP (mmHg)
aET-RA, endothelin receptor antagonist; SNX, subtotal nephrectomy.
bP < 0.05 versus groups 1, 2, 3, and 4.
1. Sham operation 11 337 ± 16.3 31.8 ± 2.5 0.36 ± 0.03 13.4 ± 1.12 100 ± 17
2. Sham operation + ET-RA 10 347 ± 15.7 40.4 ± 12.4 0.43 ± 0.06 11.4 ± 2.14 100 ± 17
3. Sham operation + mesenteric artery ligation 10 334 ± 12.3 36.2 ± 7.0 0.36 ± 0.04 14.3 ± 1.00 108 ± 11
4. Sham operation + mesenteric artery ligation + ET-RA 12 337 ± 10.6 35.4 ± 5.9 0.38 ± 0.03 13.4 ± 1.27 103 ± 19
5. SNX 15 341 ± 12.6 69.4 ± 13.1b 0.64 ± 0.09b 13.0 ± 0.80 131 ± 12b
6. SNX + ET-RA 14 338 ± 7.8 69.7 ± 10.9b 0.68 ± 0.07b 13.4 ± 1.39 135 ± 14b
7. SNX + mesenteric artery ligation 13 334 ± 10.3 70.7 ± 11.7b 0.63 ± 0.07b 14.0 ± 1.44 134 ± 14b
8. SNX + mesenteric artery ligation + ET-RA 15 337 ± 9.5 85.0 ± 10.7b 0.70 ± 0.07b 13.6 ± 1.83 132 ± 10b
ANOVA 100 NS P < 0.05 P < 0.05 NS P < 0.05