Table 2.

Quantitative morphologic assessments of first-order mesenteric arteries

Groups No. of Animals Lumen Diameter (μm) Intimal Thickness (μm) Medial Thickness (μm) Wall/Lumen Ratio (μm/μm × 10-3)
aLow flow, first-order mesenteric branches with ligation of the daughter second-order branches (see Figure 1).
bP < 0.05 versus all other groups.
cP < 0.05 versus groups 5 and 7a.
dP < 0.05 versus group 8b.
eP < 0.05 versus groups 7a and 8b.
fBy Kruskal-Wallis test.
1. Sham operation 5 210 ± 63.9 2.40 ± 0.35 14.0 ± 2.26 84.0 ± 21.0
2. Sham operation + ET-RA 5 208 ± 42.7 1.28 ± 0.35 12.9 ± 1.24 70.7 ± 14.7
3. Sham operation + mesenteric artery ligation
low flowa (a) 5 189 ± 23.0 1.38 ± 0.77 13.9 ± 5.68 82.5 ± 34.0
high flow (b) 231 ± 68.8 1.78 ± 0.34 15.1 ± 5.79 75.4 ± 26.8
4. Sham operation + mesenteric artery ligation + ET-RA
low flow (a) 7 227 ± 28.1 2.62 ± 1.55 14.2 ± 2.89 74.0 ± 12.3
high flow (b) 286 ± 62.1 1.64 ± 0.81 16.4 ± 3.37 64.3 ± 10.9
5. SNX 9 196 ± 62.2 2.06 ± 0.61 16.2 ± 4.68 110 ± 74.2
6. SNX + ET-RA 9 207 ± 37.2 1.80 ± 0.48 15.5 ± 2.89 87.5 ± 26.7
7. SNX + mesenteric artery ligation
low flow (a) 8 185 ± 58.9 4.21 ± 1.39b 13.8 ± 3.67 102 ± 21.7
high flow (b) 266 ± 80.3c 2.09 ± 1.00d 19.5 ± 3.61e 86.1 ± 22.2
8. SNX + mesenteric artery ligation + ET-RA
low flow (a) 10 233 ± 53.2 1.20 ± 0.71 16.4 ± 2.71 79.7 ± 25.0
high flow (b) 289 ± 43.0 0.92 ± 0.83 15.5 ± 1.94 58.7 ± 15.1
ANOVA or Kruskal-Wallis test P < 0.05 P < 0.0001 P < 0.05 P < 0.05f