Table 3.

Cell proliferation evaluated in PCNA immunohistochemical analysesa

Groups No. of Animals PCNA-Positive Cells (no./mm2 area)
Intima Media
aPCNA, proliferating cell nuclear antigen.
bP < 0.05 versus groups 1, 2, 3, and 4.
cP < 0.05 versus groups 1, 2, 3, 4, 6, 7b, and 8.
dP < 0.05 versus groups 1, 2, 3, 4, 6, and 8.
1. Sham operation 6 484 ± 423 477 ± 383
2. Sham operation + ET-RA 5 466 ± 518 564 ± 361
3. Sham operation + mesenteric artery ligation
low flow (a) 5 0 244 ± 196
high flow (b) 353 ± 532 517 ± 130
4. Sham operation + mesenteric artery ligation + ET-RA
low flow (a) 5 0 27 ± 53
high flow (b) 206 ± 274 146 ± 83
5. SNX 6 1939 ± 1633b 699 ± 75
6. SNX + ET-RA 5 1133 ± 1217 627 ± 249
7. SNX + mesenteric artery ligation
low flow (a) 5 1692 ± 702c 1098 ± 834d
high flow (b) 549 ± 672 683 ± 182
8. SNX + mesenteric artery ligation + ET-RA
low flow (a) 5 0 608 ± 351
high flow (b) 0 617 ± 305
Kruskal-Wallis test P < 0.0001 P < 0.0005