Table 2.

Micropuncture dataa

Parameter KCNE1 +/+ KCNE1 -/-
aSNGFR, single-nephron glomerular filtration rate; V-, Na-, or CI-LP/-FD, absolute delivery of fluid, Na+, or Cl- to last proximal (LP) or first distal (FD) tubular loop on kidney surface; FR, fractional delivery; K, K+. N = 45 and 33 nephrons for collection in LP or FD tubule in KCNE1 +/+ and n = 37 and 25 in KCNE1 -/-, respectively. * P < 0.05 versus KCNE1 +/+.
SNGFR proximal/distal (nl/min) 13 ± 1/12 ± 1 13 ± 1/12 ± 1
V-LP/-FD (nl/min) 7.9 ± 0.3/2.8 ± 0.2 8.5 ± 0.5/3.2 ± 0.4
FR-V-LP/-FD (%) 65.5 ± 0.9/25.2 ± 1.6 67.5 ± 2.0/24.9 ± 2.2
Na-LP/-FD (pmol/min) 875 ± 42/63 ± 6 861 ± 43/82 ± 16
FR-Na-LP/-FD (%) 51.2 ± 1.6/4.0 ± 0.3 50.4 ± 1.6/4.7 ± 0.8
FR-K-LP/-FD (%) 66.0 ± 2.2/17.1 ± 1.9 57.4 ± 1.9*/10.6 ± 0.9*
Cl-LP/-FD (pmol/min) 793 ± 33/39 ± 6 878 ± 47/65 ± 12*
FR-Cl-LP/-FD (%) 53.2 ± 1.6/2.8 ± 0.3 59 ± 1.8*/4.6 ± 0.8*