Table 3.

Systemic and whole kidney data: response to amiloridea

Parameter KCNE1 +/+ (n = 8) control/+ amiloride KCNE1 -/- (n = 8) control/+ amiloride
abw, body weight; FE, fractional excretion; * P < 0.05 versus KCNE1 +/+; # P < 0.05 versus control period.
Body weight (g) 24 ± 1 23 ± 1
MAP (mmHg) 75 ± 4/75 ± 4 93 ± 12/96 ± 10
Hematocrit (%) 45 ± 1/45 ± 1 48 ± 1/51 ± 1*
Plasma [Na+] (mM) 140 ± 3/138 ± 3 137 ± 3/136 ± 3
Plasma [K+] (mM) 6.6 ± 0.4/6.4 ± 0.3 5.5 ± 0.3*/6.0 ± 0.2
GFR (μl/min per g body wt) 11 ± 1/11 ± 1 12 ± 1/12 ± 1
UV (nl/min per g body wt) 113 ± 28/70 ± 14 109 ± 27/97 ± 14
FE fluid (%) 1.1 ± 0.3/0.6 ± 0.1 1.0 ± 0.2/0.8 ± 0.1
UNaV (nmol/min per g body wt) 2.3 ± 1.0/21.1 ± 5.2# 9.1 ± 2.2*/28.8 ± 4.8#
UKV (nmol/min per g body wt) 7.6 ± 1.5/1.8 ± 0.3# 12.2 ± 2.5/2.8 ± 0.5#