Table 2.

Renal distribution of the type IV collagenases and their related proteins during renal ontogeny and tubule segmentation in the mousea

E11.5E12.5E16.5NewbornAdult
aALH, ascending limb of Henle's loop; Cd, collecting duct; Cnt, connecting tubule; DT, distal tubule; Imes, induced mesenchyme; Mes, mesenchyme; PT, proximal tubule; UB, ureteric bud. Bold characters indicate prevailing localization of the enzyme/inhibitor in metanephros or along the renal tubule. Italics indicate predominant expression at the apical cell pole.
MMP9 Mes Imes PT-Cd PT-Cd PT-Cd
TIMP1 Mes Imes PT-ALH-DTALH-DT-CdALH-DT-Cd
MMP2 Mes Imes-UBPT-CdPT-DT-Cnt DT-Cnt
MT1-MMPMes-UBImes-UBPT-CdPT-Cnt-Cd PT-Cnt-Cd
TIMP2 Mes Imes PT PT-Cd PT-Cnt-Cd
TIMP3 Mes Imes PT-ALH-DT-CdPT-ALH-DT-CdPT-ALH-DT-Cd