Table 1.

Effect of anti-aminopeptidase A monoclonal antibodies administered to BALB/c mice

mAb CodeDose (mg)nGlomerular Enzyme ActivityAlbuminuria (μg/18 h)Angiotensin II (fmol/g wet wt)
a P < 0.001,
b P < 0.01 versus control.
Control3+++99 ± 3325 ± 17
ASD-378.04−/±202 ± 29308 ± 59
ASD-3/374.0548804 ± 12258a1811 ± 216a
ASD-3/414.05+/++396 ± 39282 ± 23
ASD-37/414.05−/±33867 ± 2990a1104 ± 183b