Table 1.

Per tertile GFR baseline characteristics of 322 patients with nondiabetic, proteinuric chronic nephropathies

ParameterLowestMiddleHighest
ConventionalRamiprilConventionalRamiprilConventionalRamipril
Patients n555256524661
GFR (ml/min per 1.73 sqm)
 range10.5 to 32.713.6 to 32.632.7 to 50.633.0 to 50.850.9 to 101.051.7 to 100.9
 mean ± SD23.4 ± 5.325.0 ± 5.241.1 ± 5.241.0 ± 5.263.0 ± 10.067.0 ± 13.3
Clinical parameters
 age (yr)50.3 ± 13.649.5 ± 12.352.3 ± 14.348.8 ± 14.046.3 ± 12.848.8 ± 14.0
 male gender (%)71%73%68%87%78%77%
 systolic BP (mmHg)147.4 ± 17.0149.4 ± 17.8146.1 ± 18.9142.9 ± 16.8143.5 ± 16.0144.1 ± 20.0
 diastolic BP (mmHg)89.3 ± 11.192.0 ± 12.790.5 ± 11.089.2 ± 9.690.8 ± 10.989.6 ± 12.5
 mean BP (mmHg)108.7 ± 11.1111.2 ± 13.2109.0 ± 12.6107.1 ± 10.790.8 ± 10.7107.7 ± 14.0
Diagnosis
 glomerular disease (%)35%50%52%60%57%64%
 APKD or interstitial  nephritis (%)11%10% 9% 2% 2% 6%
 other or unknown (%)54%40%39%38%41%30%
Laboratory parameters
 serum creatinine (mg/dl)3.2 ± 0.73.1 ± 0.92.0 ± 0.42.0 ± 0.41.5 ± 0.31.4 ± 0.3
 creatinine clearance (ml/min  per 1.73 sqm)29.4 ± 9.231.0 ± 12.546.8 ± 11.848.3 ± 12.167.5 ± 15.771.1 ± 19.1
 proteinuria (g/24 h)3.7 ± 2.24.1 ± 3.33.2 ± 2.33.6 ± 2.93.1 ± 2.32.8 ± 2.0
 total cholesterol (mg/dl)238.8 ± 59.5237.9 ± 54.0250.7 ± 51.1243.8 ± 68.0245.4 ± 53.2247.0 ± 83.0
 triglycerides (mg/dl)192.8 ± 126.0195.7 ± 133.9174.4 ± 94.4172.2 ± 94.6168.9 ± 96.6214.9 ± 216.9
 potassium (mEq/l)4.7 ± 0.64.5 ± 0.64.4 ± 0.64.3 ± 0.54.3 ± 0.54.4 ± 0.4