Table 4.

Events in patients with estimated creatinine clearance >60 and ≤60 ml/min at baseline

Events No. of Events Events/1000 Patient Years Adjusted Relative Riska 95% CIaP Valuea
aP values, risk ratios, and CI are adjusted for achieved diastolic and systolic BP, age, gender, smoking habits, previous cardiovascular disease, diabetes, and total serum cholesterol.
bNonfatal myocardial infarction, nonfatal stroke, and all cardiovascular deaths.
Major cardiovascular eventsb
creatinine clearance >60 505 8.5
creatinine clearance ≤60 165 16.0 1.58 1.29-1.95 <0.001
All myocardial infarction
creatinine clearance >60 168 2.8
creatinine clearance ≤60 37 3.5 1.46 0.98-2.17 0.063
All stroke
creatinine clearance >60 211 3.5
creatinine clearance ≤60 77 7.4 1.50 1.10-2.04 0.011
Cardiovascular mortality
creatinine clearance >60 192 3.2
creatinine clearance ≤60 77 7.3 1.80 1.33-2.44 <0.001
Total mortality
creatinine clearance >60 425 7.1
creatinine clearance ≤60 157 14.9 1.65 1.34-2.03 <0.001