Table 6.

Percentage of patients with baseline serum creatinine ≤1.5 and >1.5 mg/dl achieving the diastolic targets and the corresponding mean dose titration step required

Serum Creatinine (mg/dl)
Target DBP % Achieved Target Mean Dose Step During Follow-Upa
≤1.5 mg/dl >1.5 mg/dl ≤1.5 mg/dl >1.5 mg/dl P Value
aMean dose titration step (SD) from 6 mo to the end of the study.
≤90 mmHg 87.5 89.1 2.2 (1.2) 2.5 (1.3) <0.001
≤85 mmHg 73.0 73.6 2.4 (1.3) 2.6 (1.2) NS
≤80 mmHg 47.9 47.9 2.7 (1.3) 3.2 (1.3) <0.001
All patients 69.6 71.2 2.4 (1.3) 2.8 (1.3) <0.001