Table 1.

Characteristics of the control, control paired-fed and CRF ratsa

Control Control Paired-Fed CRF
aCRF, chronic renal failure. Data are the mean ± SEM. Measurements were made 41 d after the first surgery.
bP < 0.01 compared with control rats.
cP < 0.01 compared with control paired-fed animals.
Body weight (g) 459 ± 3.7 318 ± 9.4b 327 ± 8.5b
Serum creatinine (μmol/L) 52 ± 1 56 ± 2 141 ± 9b,c
Creatinine clearance (μl/100 g of body weight/min) 406 ± 18 390 ± 17 178 ± 25b,c
Serum urea (mmol/L) 4.8 ± 0.2 5.9 ± 0.5 24.5 ± 5.8b,c
Liver total cytochrome P450 activity (nmol/mg of proteins) 0.61 ± 0.01 0.59 ± 0.04 0.34 ± 0.04b,c