Table 1.

Systemic and renal functional parameters in control, treated, and untreated PHN ratsa

ParametersControlPHNPHN + LisinoprilcPHN + L-158,809c
7 D2 Mo4 Mo8 Mo7 D4 Mo8 Mob
aData are expressed as mean ± SD. PHN, passive Heymann nephritis.
bP < 0.05 versus control at respective time.
cP < 0.05 versus PHN 8 mo.
Systolic BP (mmHg)114 ± 10120 ± 12121 ± 1134 ± 9118 ± 10143 ± 28156 ± 14103 ± 3113 ± 11
Proteinuria (mg/d)17 ± 316 ± 226 ± 636 ± 650 ± 21b510 ± 109b768 ± 14791 ± 30166 ± 11
Serum creatinine (mg/dl)0.5 ± 0.10.6 ± 0.10.6 ± 0.10.7 ± 0.10.7 ± 0.11.0 ± 0.2b1.6 ± 0.20.9 ± 0.10.8 ± 0.1
Glomeruli with sclerosis (%)0000.7 ± 0.80.4 ± 0.239 ± 20b76 ± 76.0 ± 0.110 ± 1
Tubulointerstitial damage (score)0000.3 ± 0.501.8 ± 0.5b3 ± 0.10.3 ± 0.30.8 ± 0.3