Table 1.

Demographics and renal presentationa

CharacteristicLCDD (n = 12)LHCDD (n = 5)HCDD (n = 6)Pure MIDD (n = 23)LCDD & MCN (n = 11)P Value
aResults are given as no. (%) or mean ± SEM. NS, not significant; HTN, hypertension; LCDD, light-chain deposition disease; LHCDD, light- and heavy-chain deposition disease; HCDD, heavy-chain deposition disease; MIDD, monoclonal immunoglobulin deposition disease; RBC, red blood cells; hpf, high-power field.
bPure MIDD versus LCDD & MCN.
cLHCDD versus LCDD & HCDD.
dLCDD versus LHCDD & HCDD.
Gender (M/F)7/52/33/312/115/6NS
Age (yr)56.6 ± 2.8763.8 ± 5.8853.8 ± 2.6357.4 ± 2.1267.1 ± 3.920.066b
Hypertension10 (83%)2 (40%)6 (100%)18 (78%)7 (64%)0.03c
Creatinine (mg/dl)4.0 ± 0.95.3 ± 2.04.8 ± 1.54.5 ± 0.77.8 ± 1.20.01b
Renal insufficiency (sCr ≥1.2 mg/dl)11 (92%)5 (100%)6 (100%)22 (96%)11 (100%)NS
Proteinuria (g/24 h)4.2 ± 0.82.9 ± 1.05.3 ± 2.24.2 ± 0.72.2 ± 0.70.01b
Nephrotic proteinuria (≥3 g/24 h)6 (50%)1 (20%)4 (67%)11 (48%)2 (18%)NS
Albumin (g/dl)3.6 ± 0.22.8 ± 0.22.9 ± 0.33.2 ± 0.23.6 ± 0.2NS
Cholesterol (mg/dl)275.4 ± 17.2215 ± 12.1212.5 ± 26.7246.3 ± 14.0218 ± 23.10.05d
Edema5 (42%)5 (100%)5 (83%)15 (65%)2 (18%)0.01b
Nephrotic syndrome2 (17%)1 (20%)3 (50%)6 (26%)0 (0%)NS
Microhematuria (>5 RBC/hpf)5 (42%)3 (60%)4 (67%)12 (52%)4 (36%)NS
Hypocomplementemia0 (0%)1 (20%)3 (50%)4 (17%)0 (0%)NS
Acute renal failure4 (33%)1 (20%)2 (33%)7 (30%)9 (82%)0.02b
Dialysis at time of biopsy2 (16%)2 (40%)2 (33%)6 (26%)7 (64%)0.053b