Table 1. Half-maximal inhibition (IC50) value of pentosidine or Nε-carboxymethyllysine (CML) formation during incubation of diabetic, uremic, or diabetic uremic plasmaa

CompoundIC50 (mM)
PentosidineCML
Diabetic PlasmaUremic PlasmaDiabetic Uremic PlasmaDiabetic PlasmaUremic Plasma
a Diabetic plasma, predialysis uremic plasma, or predialysis diabetic uremic plasma was incubated at 37°C for 1 wk in the presence of several concentrations of the tested compounds. The yields of pentosidine and CML in the incubation mixtures were determined by HPLC and gas chromatography/mass spectrometry (GC/MS), respectively.
Olmesartan1.391.711.993.704.54
Temocaprilat1.802.402.124.656.63
Nifedipine>20>20>20>20>20
Aminoguanidine6.758.276.702.655.43
Pyridoxamine4.415.423.315.3111.70
OPB-91950.490.500.500.601.48