Table 5. Half-maximal inhibition (IC50) value of the post-Amadori pentosidine formationa

CompoundIC50 (mM)
Preglycation with ArabinosePreglycation with Ribose
a BSA was incubated with 0.5 M arabinose or ribose for 24 h at 37°C, followed by extensive dialysis at 4°C. AGE formation was initiated in the presence of various concentrations of the tested compounds by subsequently incubating the Amadori-rich proteins (30 mg/ml) in 0.1 M phosphate buffer (pH 7.4) at 37°C for 1 wk. The content of pentosidine generated upon incubation was determined by HPLC.
Olmesartan6.228.81
Temocaprilat10.8011.20
Nifedipine>50>50
Aminoguanidine1.586.94
Pyridoxamine13.0011.20
OPB-91950.614.90