Table 1. Mesangial expression of Smad6 and Smad7 in human biopsiesa

FSGS (n = 7)MCD (n = 6)MNP (n = 8)LN (n = 6)DN (n = 6)
a Immunohistological staining for Smad6 and Smad7 was performed on a random series of human glomerular diseases. The staining was semiquantitatively ranked for equal or enhanced expression compared to normal specimen. Numbers represent cases in each group. FSGS, focal segmental glomerulosclerosis; MCD, minimal-change disease; MNP, membranous nephropathy; LN, lupus nephritis; DN, diabetic nephropathy.
Smad6 expression equal to normal42123
Smad6 expression enhanced34743
Smad7 expression equal to normal32453
Smad7 expression enhanced44413