Table 1. Effect of androgen receptor antagonism or insensitivity on plasma renin concentrations (PRC) and activities (PRA), angiotensinogen, and kidney renin mRNA levels

Control n = 7Flutamide n = 6tfm-Negative n = 7tfm-Positive n = 7
a P < 0.05, b P < 0.01, significantly different Flutamide group versus control group, or tfm-positive group versus tfm-negative group.
Rat PRC (ng AngI/ml per h)33.8 ± 9.627.6 ± 2.718.1 ± 1.612.7 ± 1.8a
Rat PRA (ng AngI/ml per h)19.7 ± 5.910.1 ± 1.512.1 ± 1.17.7 ± 0.6b
Rat renin mRNA (% of control)100 ± 14.855.6 ± 6.2a100 ± 51.9137.2 ± 18.9
Mouse PRC (ng AngI/ml per h)44.8 ± 6.430.2 ± 1.5a35.3 ± 3.624.9 ± 1.7a
Mouse PRA (ng AngI/ml per h)30.5 ± 3.716.9 ± 1.0b18.4 ± 5.220.9 ± 4.4
Mouse renin mRNA (% of control)100 ± 11.844.1 ± 2.9b100 ± 23.0133.5 ± 12.9
Plasma angiotensinogen (μg/ml)1.3 ± 0.21.6 ± 0.11.2 ± 0.11.0 ± 0.04