Table 2. Effect of androgen receptor antagonism or insensitivity on plasma levels of testosterone, estrogens, luteinizing (LH), and follicle-stimulating (FSH) hormones

Control n = 7Flutamide n = 6tfm-Negative n = 7tfm-Positive n = 7
a P < 0.05, b P < 0.01, c P < 0.001, significantly different Flutamide group versus control group, or tfm-positive group versus tfm-negative group.
Testosterone (nmol/L)7.5 ± 1.5117.1 ± 14.7c5.0 ± 1.613.7 ± 2.4a
Estrogen (pmol/L)28.3 ± 2.150.7 ± 1.9c35.8 ± 4.966.3 ± 8.2c
Rat LH (μg/L)0.5 ± 0.17.1 ± 0.8c0.8 ± 0.16.4 ± 0.3c
Rat FSH (μg/L)7.8 ± 0.817.2 ± 1.9c7.7 ± 1.219.5 ± 1.3b