Table 3.

Crude and adjusted relative risks of fatal and nonfatal cardiovascular eventsa

Variables (Units of Increase)Model 1 (Unadjusted)Model 2Model 3Model 4
Hazard RatioP ValueHazard RatioP ValueHazard RatioP ValueHazard RatioP Value
a Data are expressed as hazard ratios, 95% confidence interval, and P values. Data adjustment for traditional risk factors (model 2), as well as for factors peculiar to end-stage renal disease (ESRD) (model 3) and emerging risk factors (model 4), did not modify the relationship between adiponectin (ADPN) levels and cardiovascular events.
ADPN levels (1 μg/ml)0.97 (0.93 to 0.99)0.030.96 (0.93 to 0.99)0.030.96 (0.93 to 0.99)0.020.97 (0.93 to 0.99)0.04
Framingham risk factors
 age (1 yr)1.02 (0.99 to 1.04)0.141.02 (1.00 to 1.04)0.061.03 (1.00 to 1.05)0.02
 male gender1.19 (0.65 to 2.17)0.571.35 (0.72 to 2.53)0.351.31 (0.70 to 2.46)0.40
 smoking1.22 (0.69 to 2.16)0.491.15 (0.65 to 2.04)0.631.10 (0.61 to 2.00)0.75
 systolic pressure (1 mmHg)1.00 (0.99 to 1.01)0.891.00 (0.99 to 1.02)0.511.00 (0.99 to 1.01)0.66
 cholesterol level (1 mg/dl)1.00 (0.99 to 1.01)0.211.00 (0.99 to 1.01)0.151.00 (0.99 to 1.01)0.30
 diabetes mellitus1.11 (0.59 to 2.09)0.751.48 (0.75 to 2.96)0.261.72 (0.85 to 3.48)0.13
 LVH (echocardiography)2.95 (1.28 to 6.79)0.012.14 (0.88 to 5.20)0.091.94 (0.79 to 4.78)0.15
 previous cardiovascular events2.38 (1.39 to 4.05)0.0012.05 (1.17 to 3.58)0.012.16 (1.22 to 3.80)0.008
Factors peculiar to ESRD
 hemoglobin levels (1 g/dl)1.03 (0.88 to 1.20)0.711.01 (0.86 to 1.17)0.92
 albumin levels (1 g/dl)0.84 (0.47 to 1.50)0.540.77 (0.43 to 1.39)0.39
 calcium phosphate (1 mmol2/L2)1.10 (0.86 to 1.40)0.451.12 (0.87 to 1.44)0.37
 duration of RDT (10 mo)1.04 (1.00 to 1.08)0.041.04 (1.00 to 1.08)0.04
Emerging risk factors
 CRP levels (1 mg/L)0.99 (0.98 to 1.01)0.40
 homocysteine levels (10 μM)1.10 (1.01 to 1.19)0.03