Table 4.

Outcome after index biopsy—C4d-positive versus C4d-negative patientsa

Patient GroupsNumber of PatientsS-Creatinine (μmol/L)1 yr after Index Biopsy Mean ± SD (Median)Graft Failure 1 yr after Index Biopsy % (nb)
a The s-creatinine levels refer to functioning grafts only. %, rate of graft failure. Index biopsy, patient’s first available C4d-positive or C4d-negative biopsy. S-creatinine levels and graft failure rates between C4d-positive and C4d-negative patients: differences not significant.
b Evaluable number of patients 12 mo after index biopsy.
All patients
 C4d-positive94172 ± 66 (159)14% (86)
 C4d-negative171181 ± 88 (153)10% (147)
Index biopsies within 38 d posttransplantation
 C4d-positive51161 ± 58 (142)18% (45)
 C4d-negative38173 ± 84 (137)27% (30)
Index biopsies within 180 d posttransplantation
 C4d-positive65164 ± 53 (153)15% (58)
 C4d-negative91184 ± 100 (154)12% (62)
Index biopsies after 180 d posttransplantation
 C4d-positive29191 ± 86 (168)15% (26)
 C4d-negative80178 ± 75 (150)4.1% (73)
Patients with cadaveric transplants
 C4d-positive63179 ± 75 (161)16% (57)
 C4d-negative117183 ± 91 (153)13% (104)
Patients with transplants of living donor origin
 C4d-positive31158 ± 41 (156)21% (29)
 C4d-negative54177 ± 82 (152)5% (43)