Table 5.

Therapy and outcome after index biopsy—C4d-positive versus C4d-negative patientsa

Patient GroupsNumber of PatientsS-Creatinine (μmol/L)1 yr after Index Biopsy Mean ± SD (Median)Graft Failure 1 yr after Index Biopsy % (nb)
a The s-creatinine levels refer to functioning grafts only. %, rate of graft failure. S-creatinine levels and graft failure rates between C4d-positive and C4d-negative patients: differences not significant.
b Evaluable number of patients 12 mo after index biopsy.
Treatment with ATG or OKT3
 C4d-positive51167 ± 65 (150)20% (49)
 C4d-negative27229 ± 140 (179)27% (26)
Treatment with bolus steroids only
 C4d-positive26169 ± 37 (172)14% (21)
 C4d-negative62175 ± 79 (149)14% (51)
No specific antirejection treatment
 C4d-positive17187 ± 95 (167)13% (16)
 C4d-negative79170 ± 68 (149)9% (69)