Table 1.

Effects of probenecid, dipyridamole, and nucleosides on MRP4-mediated, ATP-dependent, [3H]cGMP transporta

CompoundConcentration (μM)[3H]cGMP Uptake (% of Control)
a Membrane vesicles from Sf9-MRP4 cells were incubated with 1 μM [3H]cGMP for 10 min at 37°C, in the absence (control) or presence of various compounds. Net ATP-dependent uptake was expressed as a percentage of control uptake. Data represent mean ± SEM values of three determinations. MRP4, multidrug resistance protein 4.
b P < 0.05.
c P < 0.01 (ANOVA with Bonferroni’s correction).
No inhibitor100
Probenecid1086 ± 4b
10040 ± 3c
100010 ± 3c
cAMP1078 ± 26
5060 ± 7c
25036 ± 9c
Dipyridamole19 ± 3c
Adefovir198 ± 7
1000102 ± 9
Cidofovir1100 ± 4
100097 ± 12